Huntington Disease is known for neurodegeneration occurring at what stage of life?

• A. Early childhood
• B. Middle Age
• C. Adolescence
• D. Senior Age

Answer: (B)

Huntington Disease is characterized by neurodegeneration that typically manifests in middle age, specifically from around the ages of 30 to 50. This timing is significant because individuals often exhibit no symptoms until they reach adulthood, despite inheriting the genetic mutation earlier in life. The disease is caused by a mutation in the HTT gene, leading to a progressive decline in cognitive, motor, and psychiatric functions.

Symptoms often begin with subtle changes, such as mood swings or difficulty with concentration, before advancing to more severe motor and cognitive impairments. Identifying the age of onset as middle age is crucial for understanding the disease's impact on individuals and their families, as it often coincides with peak responsibilities in life, such as career and family.