What is the gene product associated with Rett syndrome?

• A. Metallopeptidase
• B. Methyl-CpG-binding protein-2
• C. NF-B essential modulator
• D. Unknown

Answer: (B)

Rett syndrome is a neurodevelopmental disorder that primarily affects females and is often caused by mutations in the MECP2 gene. The gene product associated with Rett syndrome is the Methyl-CpG-binding protein-2. This protein plays a crucial role in regulating gene expression by binding to methylated DNA, which is important for normal brain development and function.

Mutations in the MECP2 gene disrupt the function of the Methyl-CpG-binding protein-2, leading to the various symptoms associated with Rett syndrome, including loss of purposeful hand skills, speech impairment, and motor difficulties. The other options do not directly relate to the genetic basis of Rett syndrome, highlighting the specificity of MECP2's role in this condition.