Which type of inheritance does Aniridia fall into?

• A. Autosomal Recessive
• B. Autosomal Dominant
• C. X-linked Dominant
• D. Mitochondrial

Answer: (B)

Aniridia is classified as an autosomal dominant disorder. This means that only one copy of the mutated gene inherited from a parent is sufficient to cause the condition. Aniridia is primarily associated with mutations in the PAX6 gene, which plays a crucial role in eye development.

In autosomal dominant inheritance, the affected individual has a 50% chance of passing the mutation to each of their offspring, irrespective of the offspring's sex. This pattern of inheritance accounts for the occurrence of Aniridia in both males and females equally, further supporting its classification as autosomal dominant.

Additionally, the expression of Aniridia in affected individuals can be variable, resulting in a range of symptoms, but the presence of the mutated allele is enough to demonstrate the trait, which is characteristic of autosomal dominant conditions.